Heterocyclic substitutions greatly improve affinity and stability of folic acid towards fr. an in silico insight

HIGHLIGHTS

• who: Mohammad G. Al-Thiabat and colleagues from the School of Pharmaceutical Sciences, Universiti Sains Malaysia, Gelugor, Penang, Malaysia have published the research work: Heterocyclic Substitutions Greatly Improve Affinity and Stability of Folic Acid towards FR. an In Silico Insight, in the Journal: Molecules 2021, 26, x FOR PEER REVIEW of 22/02/2021
• what: In the present study, nineteen new FA analogs were designed containing heterocyclic rings recently incorporated in anticancer agents and their effect on the binding affinity towards FRα was investigated . The fluctuations of residues near the docking pocket key role in . . .
  

   

  

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