Heterozygous expression of a kcnt1 gain-of-function variant has differential effects on somatostatin- and parvalbumin-expressing cortical gabaergic neurons

HIGHLIGHTS

• What: Despite the potential limitations, this study provides three major findings that advance the understanding of the relationship between ion_channel function and disease.
• Who: Neuroscience and colleagues from the of Vermont, Burlington, VT, Department of Pharmaceutical, UNT have published the Article: Heterozygous expression of a Kcnt1 gain-of-function variant has differential effects on SST- and PV- expressing cortical GABAergic neurons, in the Journal: (JOURNAL)
• How: Together these data showed that as hypothesized KCNT1 GOF indeed strongly reduces the excitability of SST neurons but unexpectedly it also causes a hyperexcitable effect in PV . . .
  

   

  

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