HIGHLIGHTS
- who: Shiden Solomon from the Department of Basic and Clinical Neuroscience, Institute London, London, UK University of Oxford, Oxford, UK have published the paper: Heterozygous expression of the Alzheimer’s disease-protective PLCγ2 P522R variant enhances Aβ clearance while preserving synapses, in the Journal: (JOURNAL)
- what: The authors demonstrate that the heterozygous PLCγ2P522R protective variant modulates microglia-mediated Aβ and synaptosome uptake, which may underpin its protective nature in_vivo. The authors show a potential impact of PLCγ2P522R on microglia mitochondrial function and ATP production, which may contribute to maintenance of microglia metabolic . . .
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