Hierarchical activation of compartmentalized pools of ampk depends on severity of nutrient or energy stress

HIGHLIGHTS

• who: Yue Zong from the (UNIVERSITY) have published the research: Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress, in the Journal: (JOURNAL)
• what: The authors have systemically evaluated how compartmentalized pools of AMPK are regulated, and how different subcellular targets of AMPK are phosphorylated in response to different severities of nutrient or energy stress. The authors demonstrate that in MEFs starved for glucose or the livers of mice starved for 16 h, when AMP:ATP or ADP:ATP ratios remained unchanged, AMPK activation occurs exclusively in the lysosomal . . .
  

   

  

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