HIGHLIGHTS
- who: Kevin E.W. Namitz from the University of New York (SUNY) Upstate Medical University, Department of Biochemistry have published the research: Hierarchical assembly of the MLL1 core complex regulates H3K4 methylation and is dependent on temperature and component concentration, in the Journal: (JOURNAL) of 29/Nov/2022
- what: While pairwise interactions between complex subunits have been determined the mechanisms regulating holo-complex assembly are unknown. this investigation the authors systematically characterized the biophysical properties of a reconstituted human MLL1 core complex and found that the MLL1-WDR5 heterodimer interacts with the RbBP5-Ash2L-DPY30 . . .
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