Hif-1α triggers er stress and chop-mediated apoptosis in alveolar epithelial cells, a key event in pulmonary fibrosis

HIGHLIGHTS

• who: from the (UNIVERSITY) have published the Article: HIF-1α triggers ER stress and CHOP-mediated apoptosis in alveolar epithelial cells, a key event in pulmonary fibrosis, in the Journal: (JOURNAL)
• what: The aims of this study were: to determine whether HIF-1α and CHOP proteins were co-expressed by AECs in lung tissue from IPF patients; to evaluate whether micro-environmental hypoxia could activate the UPR pathways in rat AECs; to decipher the molecular mechanisms linking hypoxia, HIF-1α, ER stress and apoptosis in these cells. In Fig 7A, the authors show that the . . .
  

   

  

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