High-dose primaquine induces proximal tubular degeneration and ventricular cardiomyopathy linked to host cells mitochondrial dysregulation

HIGHLIGHTS

  • who: Atthasit Rabiablok and collaborators from the Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Ratchawithi Road, Ratchathewi, Bangkok, Thailand have published the article: High-Dose Primaquine Induces Proximal Tubular Degeneration and Ventricular Cardiomyopathy Linked to Host Cells Mitochondrial Dysregulation, in the Journal: Toxics 2023, 11, 146. of /2023/
  • what: In this study toxicopathological studies were conducted on a rat model to determine the effect of PQ on affected tissues and toxicity. Regarding the risk/benefit ratio of drug administration the research provides caution for the use of PQ in the treatment . . .

     

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