High-fat diet exacerbates cognitive decline in mouse models of alzheimer`s disease and mixed dementia in a sex-dependent manner

HIGHLIGHTS

  • who: Olivia J. Gannon from the Department of Neuroscience and Experimental Therapeutics, Albany Medical College, New Scotland have published the research: High-fat diet exacerbates cognitive decline in mouse models of Alzheimer`s disease and mixed dementia in a sex-dependent manner, in the Journal: (JOURNAL)
  • what: In the current study, using mouse models of both AD and MxD, the authors found that diet-induced obesity with prediabetes led to a wider array of cognitive deficits and neuropathology in females compared to males. The authors show that these sex differences persist in the MxD model . . .

     

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