High ploidy large cytoplasmic megakaryocytes are hematopoietic stem cells regulators and essential for platelet production

HIGHLIGHTS

• who: Shen Y. Heazlewood from the Mice C Bl/, (MK-LCMWT/WT) mice were purchased from the Monash Animal Research Platform (MARP, Monash University, Australia)Mice carrying the floxed serine-arginine rich splicing factor , (Srsf, fl/fl) conditional allele, were crossed with C BL/6-Tg(Pf4-icre)Q Rsko/J mice to generate platelet factor, (Pf4)-Cre-Srsf, KO (MK-LCMu0394/u0394) mice, where deletion of exon , and , of Srsf, was under the control of the Pf, promoter. Pf4-Cre-Srsf, KO mice were bred with RFP mice ubiquitously expressing a cytoplasmic pbActin-CMV-DsRed , transgene . . .
  

   

  

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