High-throughput mutagenesis identifies mutations and rna-binding proteins controlling cd19 splicing and cart-19 therapy resistance

HIGHLIGHTS

• who: Mariela Cortu00e9s-Lu00f3pez from the Institute University Medical Mainz, Mainz, Germany have published the article: High-throughput mutagenesis identifies mutations and RNA-binding proteins controlling CD19 splicing and CART-19 therapy resistance, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: Unlike previous mutagenesis screens, the authors determine all intronic and exonic mutation effects in a 1.2 kb region and quantify the abundance of 100 alternative isoforms, including intron 2 retention and alternative 3u2032/5u2032 splice site usage. CD19 exon 2 may require more specific perturbations and as the authors show here, does not . . .
  

   

  

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