HIGHLIGHTS
- who: Dan Zhu and colleagues from the (UNIVERSITY) have published the research work: High-Throughput Profiling of Cas12a Orthologues and Engineered Variants for Enhanced Genome Editing Activity, in the Journal: (JOURNAL) of 10/05/2019
- what: The authors report a high-throughput comparative profiling of activities across Cas12a orthologues in human cells by constructing genome-integrated self-cleaving paired crRNA-target libraries containing >40 guide RNAs. By generating novel engineered Cas12a variants, the authors aimed to expand the CRISPR/Cas12a toolbox and to improve their targeting capabilities and flexibility, which would facilitate further Cas12a-based . . .
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