High-throughput shape analysis reveals structures in hiv-1 genomic rna strongly conserved across distinct biological states

HIGHLIGHTS

• who: PLoS BIOLOGY et al. from the University of have published the research: High-Throughput SHAPE Analysis Reveals Structures in HIV-1 Genomic RNA Strongly Conserved across Distinct Biological States, in the Journal: (JOURNAL)
• what: The authors couple SHAPE chemistry with automated data readout and analysis systems so that hundreds of nucleotides of RNA structure can be analyzed in a single experiment. The authors also identify other sites with smaller AT-2-induced reactivity changes, which the authors characterize as secondary (single asterisks; positions 224-227 and 308-312, Figure 4A) and tertiary sites (positions . . .
  

   

  

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