High-throughput small molecule screen identifies inhibitors of microsporidia invasion and proliferation in c. elegans

HIGHLIGHTS

• who: Brandon M. Murareanu from the (UNIVERSITY) have published the research: High-throughput small molecule screen identifies inhibitors of microsporidia invasion and proliferation in C. elegans, in the Journal: (JOURNAL) of 15/09/2022
• what: The authors develop a high-throughput screening method for the identification of chemical inhibitors of microsporidia infection, using liquid cultures of Caenorhabditis elegans infected with the microsporidia species Nematocida parisii. The authors show that two irreversible serine protease inhibitors (ZPCK and TPCK) can block firing and prevent invasion.
• how: To quantify the inhibitory effect of each compound the . . .
  

   

  

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