Higher ambient synaptic glutamate at inhibitory versus excitatory neurons differentially impacts nmda receptor activity

HIGHLIGHTS

• who: Lulu Yao from the SchoolPeking University have published the paper: Higher ambient synaptic glutamate at inhibitory versus excitatory neurons differentially impacts NMDA receptor activity, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors examined the potential contributions of GluN2 subunits and synaptic glutamate concentration to the selective potentiation of synaptic NMDAR responses by GNE8324. The authors provide substantial evidence that the preferential enhancement of NMDAR EPSCs in inhibitory neurons vs. excitatory neurons by the GluN2A PAM GNE-8324 is mediated by a higher ambient synaptic glutamate level, and that this higher glutamate level . . .
  

   

  

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