Highly synchronized cortical circuit dynamics mediate spontaneous pain in mice

HIGHLIGHTS

  • who: Shiqian from the Department of Technology, Cambridge MA, USAThe University have published the research work: Highly synchronized cortical circuit dynamics mediate spontaneous pain in mice, in the Journal: (JOURNAL)
  • what: Using a clinically relevant mouse model of neuropathic pain with spontaneous pain-like behavior the authors report that orofacial spontaneous pain activated a specific area within the primary somatosensory cortex (S1) displaying synchronized neural dynamics revealed by intravital two-photon calcium imaging.
  • how: The authors developed a novel pain model for inducing neuropathic pain via a simple impingement of the trigeminal nerve . . .

     

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