Hijacking the human complement inhibitor c4b-binding protein by the sporozoite stage of the plasmodium falciparum parasite

HIGHLIGHTS

  • who: Ayman Khattab et al. from the Federal University of Pernambuco, Brazil have published the research work: Hijacking the human complement inhibitor C4b-binding protein by the sporozoite stage of the Plasmodium falciparum parasite, in the Journal: (JOURNAL)
  • what: In this report, the authors show that SPZs capture C4bp to their surfaces via the SPZ major surface circumsporozoite protein (CSP).
  • how: Binding of radiolabeled C4bp to the SPZ surface SPZs freshly isolated from salivary glands of P. falciparuminfected mosquitoes were tested for their ability to bind radiolabeled C4bp (125I-C4bp) in 20% sucrose . . .

     

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