Histone deacetylase 3 indirectly modulates tubulin acetylation

HIGHLIGHTS

  • who: Biochem. J. ( and colleagues from the Faculty University of have published the article: Histone deacetylase 3 indirectly modulates tubulin acetylation, in the Journal: (JOURNAL)
  • what: MI192 was solubilized in DMSO (Sigma), and all MI192 concentrations in the experiments described here were delivered in 0.1 % DMSO.

SUMMARY

    The authors found that blocking HDAC3 activity using MI192, a compound specific for HDAC3, modulated tubulin acetylation in the human prostate cancer cell line PC3. Analysis of HDAC3-GFP localization showed T. Bacon and others Overexpression of HDAC3 reduces levels of tubulin acetylation . . .

     

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