HIGHLIGHTS
- who: Elizabeth W. Bradley from the (UNIVERSITY) have published the Article: Histone Deacetylase 3 Suppression Increases PH Domain and Leucine-rich Repeat Phosphatase (Phlpp)1 Expression in Chondrocytes to Suppress Akt Signaling and Matrix Secretion*, in the Journal: (JOURNAL) of September/28,/2012
- how: In this study the function of Hdac3 during chondrocyte differentiation was further explored in this Hdac3-CKOOsx mouse model.
SUMMARY
Ultimately, chondrocytes undergo apoptosis, the tissue becomes vascularized and osteoblasts and osteoclasts replace the cartilaginous matrix with a type I collagen-rich mineralized matrix. The molecular roles . . .
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