HIGHLIGHTS
- who: Let#_#x00ED and colleagues from the Departamento Bioquı́mica, Instituto Quı́mica, Universidade São Paulo, São Paulo, Brazil have published the research: Histone deacetylase inhibition modulates histone acetylation at gene promoter regions and affects genome-wide gene transcription in Schistosoma mansoni, in the Journal: (JOURNAL) of March/30,/2017
- what: This approach showed affected genes associated with other histone modifications which led the authors to test and identify a synergistic schistosomicidal agent GSK343 an EZH2 histone methyltransferase inhibitor. The authors report the histone acetylation status and the large-scale gene_expression transition . . .
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