HIGHLIGHTS
SUMMARY
The authors first studied Dmd gene_expression at several exon-exon junctions in skeletal and cardiac muscles of 3-month-old mdx mice and their WT controls (C57/BL10 mice). The quantification of Dmd gene_expression at several exon-exon junctions by qPCR in muscles from HDACi-treated mice revealed a tendency for some HDACi to increase Dmd expression levels, such as EX527 in the proximal exon junctions (4-5 and 24) for all muscles or givinostat across all exon junctions in the diaphragm. To investigate whether the higher protein restoration obtained with the combined therapy . . .
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