Histone deacetylase inhibitors mitigate antipsychotic risperidone-induced motor side effects in aged mice and in a mouse model of alzheimer`s disease

HIGHLIGHTS

• who: Guadalupe Rodriguez from the Shanghai Changzheng Hospital, China Department of and Sciences, Northwestern University Feinberg School of have published the research: Histone deacetylase inhibitors mitigate antipsychotic risperidone-induced motor side effects in aged mice and in a mouse model of Alzheimer`s disease, in the Journal: (JOURNAL)
• what: The authors evaluated whether the typical antipsychotic drug RIS could induce more severe side effects on 5xFAD mice at 12 months of age, when the memory deficits and neuropathology manifest, and whether HDAC inhibitors could reverse such side effects. The authors showed significant reduction of both . . .
  

   

  

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