Histone h3.3 k27m chromatin functions implicate a network of neurodevelopmental factors including ascl1 and neurod1 in dipg

HIGHLIGHTS

• who: Nichole A. Lewis from the (UNIVERSITY) have published the research work: Histone H3.3 K27M chromatin functions implicate a network of neurodevelopmental factors including ASCL1 and NEUROD1 in DIPG, in the Journal: (JOURNAL)
• what: The authors show via analysis that H3.3K27M glioma cells have unique accessible at regions corresponding to neurogenesis NOTCH and neuronal development pathways and associated genes that are overexpressed in H3.3K27M compared to the isogenic wild-type cell line. The authors propose a model in which H3.3K27M nucleosomes cause a more euchromatic structure at super-enhancers and gene . . .
  

   

  

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