HIGHLIGHTS
- who: Bettina Sarg from the (UNIVERSITY) have published the Article: Histone H4 Hyperacetylation Precludes Histone H4 Lysine 20 Trimethylation*, in the Journal: (JOURNAL) of September/23,/2004
- what: Using a hydrophilic interaction liquid chromatographic separation method in combination with mass spectrometric analysis, this study investigated the alterations in histone H4 methylation/acetylation status and the interplay between H4 methylation and acetylation during in_vitro differentiation of mouse erythroleukemia cells and how these modifications affect the chromatin structure. Since the authors show that trimethylated H4Lys20 is localized to heterochromatin, the increase in H4-Lys20 trimethylation observed indicates . . .
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