Hiv-1 subtype c nef-mediated serinc5 down-regulation significantly contributes to overall nef activity

HIGHLIGHTS

  • who: Delon Naicker from the (UNIVERSITY) have published the article: HIV-1 subtype C Nef-mediated SERINC5 down-regulation significantly contributes to overall Nef activity, in the Journal: (JOURNAL)
  • what: The authors aimed to investigate if down-regulation activity contributes to HIV-1 disease progression to assess the relative contribution of this activity to overall function and to identify amino acids required for optimal activity. Since the model E values were able to predict individual Nef functions measured in_vitro (although not with as much accuracy as for similar models of the conserved Gag protein), E . . .

     

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