HIGHLIGHTS
- who: H Lecoeur from the Institut London , ONN, UK have published the research work: HIV-1 Tat protein directly induces mitochondrial membrane permeabilization and inactivates cytochrome c oxidase, in the Journal: (JOURNAL)
- what: The authors have investigated the potential direct effect of synthetic Tat protein (from HIV-1 Lai isolate; clade B) on mitochondria that could trigger pathogenic events. Although it is plausible that such mechanism could occur in other tissues, the authors show clearly that the direct effect of Tat on isolated mitochondria does not require such modification as the Tat effects the authors . . .
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