HIGHLIGHTS
- who: Michela Sgubin from the (UNIVERSITY) have published the article: HMGA1 positively regulates the microtubule-destabilizing protein stathmin promoting motility in TNBC cells and decreasing tumour sensitivity to paclitaxel, in the Journal: (JOURNAL) of 18/08/2021
- what: The authors demonstrate the existence of an HMGA1/ p27/stathmin axis that regulates the motility of TNBC cells. The authors show in a xenograft mouse model that HMGA1-depleted TNBC cells are more sensitive to paclitaxel. From the results obtained the authors focused on those with a clear role in tumour aggressiveness. This analysis showed an increase . . .
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