Hmga1 regulates the expression of replication-dependent histone genes and cell-cycle in breast cancer cells

HIGHLIGHTS

  • who: Sara Petrosino and collaborators from the Department of Life Sciences, University of Trieste, Trieste, Italy have published the research: HMGA1 Regulates the Expression of Replication-Dependent Histone Genes and Cell-Cycle in Breast Cancer Cells, in the Journal: (JOURNAL)
  • what: The authors show that HMGA1 participates in the activation of the HIST1H4H promoter and that it interacts with the nuclear protein of the ataxia-telangiectasia mutated locus (NPAT) the coordinator of the transcription of the RD-HIST genes. The authors demonstrate that HMGA1 silencing increases the percentage of cells in G0/G1 phase both . . .

     

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