HIGHLIGHTS
- who: Yu Du from the Department of Pharmacology and Department of Anesthesiology of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China have published the Article: HMGB1 in the mPFC governs comorbid anxiety in neuropathic pain, in the Journal: (JOURNAL)
- what: The authors aimed to investigate the role of cerebral HMGB1 in anxiety comorbidity in neuropathic pain.
SUMMARY
Local administration of monoclonal antibody against HMGB1 (anti-HMGB1 mAb) and exogenous ds-HMGB1 (the pro-inflammatory form of HMGB1) into the mPFC demonstrated the determinant role of HMGB1 in anxiety . . .
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