Hmgb1 mediates lipopolysaccharide-induced macrophage autophagy and pyroptosis

HIGHLIGHTS

• who: Jiawei Shang from the Department of Critical Care Medicine, Shanghai Jiaotong University of China have published the Article: HMGB1 mediates lipopolysaccharide-induced macrophage autophagy and pyroptosis, in the Journal: (JOURNAL)
• what: The authors investigated the role of HMGB1 in lipopolysaccharide (LPS)-induced autophagy and pyroptosis of macrophages. This study demonstrated that HMGB1 promotes LPS-induced autophagy and pyroptosis and plays different roles according to its subcellular localization.
• how: The results showed that the levels of endogenous LC3-II increased significantly at 12 h after LPS treatment and began to decrease after 24 . . .
  

   

  

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