Hnrnpk alleviates rna toxicity by counteracting dna damage in c9orf72 als

HIGHLIGHTS

• who: Elke Braems from the Brain Institute (LBI), Leuven-University Edinburgh, UK have published the research: HNRNPK alleviates RNA toxicity by counteracting DNA damage in C9orf72 ALS, in the Journal: (JOURNAL)
• what: The authors aimed to assess the relevance of C9 RNA toxicity by identifying RBPs capable of modifying a repeat RNA-induced phenotype. Using the C9orf72 zebrafish model, as well as patient fibroblasts, iPSC-derived motor neurons and post-mortem material, the authors provide evidence that HNRNPK loss-of-function contributes to disease in C9orf72 ALS. The authors show that C9 repeat RNA toxicity . . .
  

   

  

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