Homologous recombination dna repair deficiency and parp inhibition activity in primary triple negative breast cancer

HIGHLIGHTS

• who: Neha Chopra from the The Institute, Cambridge Biomedical Campus, Cambridge , QQ, United KingdomUniversity of have published the article: Homologous recombination DNA repair deficiency and PARP inhibition activity in primary triple negative breast cancer, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: In pre-planned secondary analyses, the authors show that cancers with HR deficiency can be robustly identified with the mutational-signatures based classifier HRDetect (Fig 2 and Supplementary Fig 1), which identifies cancers with a functional deficiency in HR (Fig 3b), and with evidence of activity of PARP inhibitors restricted to these cancers . . .
  

   

  

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