Hotspot: a computational tool to design targeted sequencing panels to assess early photocarcinogenesis

HIGHLIGHTS

  • who: Sydney R. Grant and collaborators from the Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA have published the research work: HotSPOT: A Computational Tool to Design Targeted Sequencing Panels to Assess Early Photocarcinogenesis, in the Journal: (JOURNAL)
  • what: Using hotSPOT, the authors show the remarkable clustering of mutations in sun-exposed normal skin, and the authors offer novel evidence for the overlap between normal skin and cSCC mutations. The authors demonstrate the ability of this software to compare mutational burden between samples by showing the mutational differences between a . . .

     

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