How functional lipids affect the structure and gating of mechanosensitive mscs-like channels

HIGHLIGHTS

SUMMARY

In this review, focus on the recent findingsFurthermore, regarding the the authors roleinclude of lipids the studiesofon the larger MscS paralogue YnaI and MscS-like plant channels MSL1 gating MscS and discuss the proposed gating mechanisms. Open conformations of MscS were also obtained under delipidating conditions, which all resemble that of the first open crystal_structure using the A106V mutant. The mechanism of how membrane tension leads to MscS channel opening remained elusive although crystal_structures showing MscS in a closed and an open conformation were acquired and several computational approaches were applied to understand the . . .

 



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