HIGHLIGHTS
- who: Anil Akbal from the (UNIVERSITY) have published the Article: How location and cellular signaling combine to activate the NLRP3 inflammasome, in the Journal: (JOURNAL) of 20/09/2022
- what: The authors discuss how these factors may control the activation of NLRP3, focusing on recent insights into the spatial and structural regulation of this inflammasome. The authors focus on the most extensively studied PTMs related to NLRP3, namely, ubiquitination and phosphorylation. As much of the work discussed in this review was performed in macrophages, the extent to which these complex mechanisms occur in other cell . . .
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