HIGHLIGHTS
SUMMARY
Present study, the authors aimed to determine the theoretical arrangement of NSP12-16 in the global structure of the CoV RTC by comprehensive analysis of data from different sources, and to preliminarily elucidate how the RTC functions in the jumping transcription of CoVs at the molecular level. In the previous study (Li et_al, 2021a), the authors provided a molecular basis for the "leader-to-body fusion" model by identifying the cleavage sites of NSP15 and proposed a negative_feedback model to explain the regulation of CoV replication and transcription. Jumping Transcription, TRS and NSP15 Cleavage . . .
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