HIGHLIGHTS
SUMMARY
The previous work demonstrated a role for the anal microbiome in anal cancer response to therapy and toxicity. The aim of this study was to identify differences in anal microbiome composition in the settings of known HPV infection, anal dysplasia, and anal cancer. Women with HPV-related highgrade dysplasia or cancer of the cervix, vagina, or vulva are at increased risk for the development of anal dysplasia and SCCA. (B) Richness of species was significantly decreased between HR Normal and Anal Dysplasia groups, (C) Shannon diversity richness index was lower in Anal Dysplasia, (D . . .
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