Hrq1/recql4 regulation is critical for preventing aberrant recombination during dna intrastrand crosslink repair and is upregulated in breast cancer

HIGHLIGHTS

• who: Thong T. Luong et al. from the University of Pittsburgh School of Medicine, Department of Pharmacology and Chemical Biology, UPMC have published the Article: Hrq1/RECQL4 regulation is critical for preventing aberrant recombination during DNA intrastrand crosslink repair and is upregulated in breast cancer, in the Journal: (JOURNAL) of September/20,/2022
• what: By identifying the targeted lysine residues the authors show that preventing Hrq1 degradation results in increased recombination and mutagenesis. Suggesting a conserved regulatory mechanism, the authors show that endogenous human RECQL4 protein levels decrease following cisplatin and acetaldehyde treatment. The authors . . .
  

   

  

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