Hsp25 inhibits protein kinase cù´-mediated cell death through direct interaction*

HIGHLIGHTS

• who: Yoon-Jin Lee from the (UNIVERSITY) have published the Article: HSP25 Inhibits Protein Kinase CÙ´-mediated Cell Death through Direct Interaction*, in the Journal: (JOURNAL) of January/31,/2005
• what: The authors show that HSP25 inhibits protein kinase C (PKC) ␦-mediated cell death through direct interaction. Based on these observations, the authors propose that after PKC␦ activation, HSP25 binds to the exposed V5 region of PKC␦.

SUMMARY

HSP25 binds to kinase-active PKC␦ to inhibit its kinase activity and translocation to the membrane, which results in reduced cell death. Coimmunoprecipitation . . .

 



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