Hsp90 activity is required for mlkl oligomerisation and membrane translocation and the induction of necroptotic cell death

HIGHLIGHTS

  • who: A V Jacobsen from the Department University of Melbourne, Parkville, VIC, Australia have published the paper: HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death, in the Journal: (JOURNAL)
  • what: The authors show that necroptosis induction by the pseudokinase MLKL is regulated by HSP90 activity.
  • how: In parallel the same library of 438 compounds was tested in Mlkl- / - MDFs reconstituted with the Q343A mutant MLKL which the authors previously showed to induce cell death in the absence of necroptotic stimuli independently of RIPK3 activity . . .

     

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