HIGHLIGHTS
- who: Eric Krawczyk and colleagues from the Department of Microbiology and Immunology, College of Medicine, University of Illinois, Chicago, IL, USA have published the Article: HSV Replication: Triggering and Repressing STING Functionality, in the Journal: Viruses 2023, 15, 226. of /2023/
SUMMARY
Mammalian cells encode multiple proteins that are capable of sensing HSV infection. Induction of STING Activity by HSV HSV infection triggers STING, a highly conserved innate immune factor. Consistently, phosphorylation of STING, TBK1, and IRF3 occurs in HSV infection leading to production of IFN. To IRF3, STING activates the transcription factor . . .
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