Human ace2 expression, a major tropism determinant for sars-cov-2, is regulated by upstream and intragenic elements

HIGHLIGHTS

• who: John N. Snouwaert et al. from the Editor: SYount, State University have published the paper: Human ACE2 expression, a major tropism determinant for SARS-CoV-2, is regulated by upstream and intragenic elements, in the Journal: (JOURNAL) of February/22,/2023
• what: Using mouse lines in which Ace2 locus has been humanized by syntenic replacement the authors show that regulation of basal and interferon induced ACE2 expression relative expression levels of different ACE2 transcripts and sexual dimorphism in ACE2 expression unique to each species differ between tissues and determined by both intragenic and upstream . . .
  

   

  

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