HIGHLIGHTS
- who: Zhihao, Chen and Ferenc A, Antoni from the (UNIVERSITY) have published the research work: Human adenylyl cyclase 9 is auto-stimulated by its isoform-speci fi c C-terminal domain, in the Journal: (JOURNAL)
- what: Given the unique regulatory features of AC9, this study investigated further the role of the C2b domain and its potential interactions with the coiled-coil. The authors show that the basal activity of WT AC9 also requires the C2b domain.
- how: Closely similar results were obtained with prostaglandin E1 as the agonist (Fig S1) and further iterations . . .
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