HIGHLIGHTS
- who: Noushin Mossadegh-Keller from the Instituto Cientı´ficas (CSIC), Spain have published the research: Human B Lymphomas Reveal Their Secrets Through Genetic Mouse Models, in the Journal: (JOURNAL)
SUMMARY
The germinal center (GC) is a specialized immune structure localized in secondary lymphoid organs-including lymph nodes, tonsils, and spleen-that forms upon antigenic challenge to support the B cell receptor (BCR) affinity maturation process. The dynamic transcriptional changes characterizing the GC cycle between LZ and DZ have been further refined through single cell gene_expression approaches revealing a continuum of cell states between . . .
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