Human centromere repositioning activates transcription and opens chromatin fibre structure

HIGHLIGHTS

• who: Catherine Naughton from the Centromeres are highly specialised genomic loci necessary to maintain genome stabilityCytogenetically they are the primary constriction of a metaphase chromosome and functionally provide an assembly site for the kinetochore, a multiprotein structure that forms attachments to the microtubules of the mitotic and meiotic spindles1. In mitosis the kinetochore is composed of a trilaminar structure with an outer layer binding to microtubules, but the architecture of the underlying chromatin fibre is unknown2. Human centromeric chromatin is assembled from CENP-A nucleosomes, and repetitive u03b1-satellite DNA sequences that span, Kb4, . Mouse acrocentric chromosomes . . .
  

   

  

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