Human enteric nervous system progenitor transplantation improves functional responses in hirschsprung disease patient-derived tissue

HIGHLIGHTS

• What: The authors describe, for the first time, the detailed characterisation of an ENS progenitor population derived from human pluripotent stem_cell (hPSC) lines using the efficient protocol. ⇒ Further, the authors demonstrate the ability of ENS progenitors to differentiate into enteric neurons in_vitro and mediate increased functional responses following transplantation into explants of human HSCR tissue. The authors demonstrate that transplantation of ENS progenitors, generated from 10 Jevans B, et_al Gut 2024;0:1-13. doi:10.1136/gutjnl-2023-331532 hPSCs using the previously described protocol24 25 and subsequent differentiation in situ, as evidenced by detection of . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or Email

  Password

  Remember me

  Lost your password?

  If you don't have an account, you can create one here.