Human glucocerebrosidase mediates formation of xylosyl-cholesterol by β-xylosidase and transxylosidase reactions

HIGHLIGHTS

• who: Daphne E. Boer from the DepartmentLeiden University, The Netherlands have published the article: Human glucocerebrosidase mediates formation of xylosyl-cholesterol by β-xylosidase and transxylosidase reactions, in the Journal: (JOURNAL)
• what: The authors show that recombinant human GBA also cleaves β-xylosides and transxylosylates cholesterol. The authors report on the in_vitro xylosylation of cholesterol by GBA, generating not only XylChol but notably also di-xylosyl-cholesterol and even small amounts of tri-xylosyl-cholesterol (Xyl2Chol and Xyl3Chol, respectively). The authors report investigations into an intriguing catalytic feature of the lysosomal glucocerebrosidase, GBA.
• how: Data . . .
  

   

  

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