Human Heme Oxygenase Oxidation of 5- and 15-Phenylhemes*

HIGHLIGHTS

• who: Jinling Wang from the (UNIVERSITY) have published the research work: Human Heme Oxygenase Oxidation of 5- and 15-Phenylhemes*, in the Journal: (JOURNAL)
• what: The authors report here that hHO-1 cleaves 5-phenylheme to biliverdin IX␣ and oxidizes 15phenylheme at the ␣-meso position to give 10-phenylbiliverdin IX␣.
• how: This result is consistent with the already described bilirubin and CO formation studies all of which suggest that 5-phenylheme is degraded enzymatically by hHO-1 without CO release probably to biliverdin IX␣.
• future: Detailed analysis of the reaction is . . .
  

   

  

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