Human ipsc-derived fallopian tube organoids with brca1 mutation recapitulate early-stage carcinogenesis

HIGHLIGHTS

• who: Nur Yucer from the Cedars-Sinai Medical Center, Los Angeles, CA, USA University of have published the article: Human iPSC-derived fallopian tube organoids with BRCA1 mutation recapitulate early-stage carcinogenesis, in the Journal: (JOURNAL) of December/28,/2021
• what: This study investigated early genomic alterations and carcinogenesis in patients with a BRCA1mut by using an iPSC-based disease model of FTE.

SUMMARY

High-grade serous cancer (HGSC) is the most common and lethal subtype of ovarian cancer, with approximately 70% of newly diagnosed ovarian cancer cases classified as HGSC . . .

 



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