HIGHLIGHTS
- who: Ju00e9ru00e9mie Rosain from the Laboratory of Human Genetics of Infectious Diseases, Inserm, Paris, France Citu00e9 University have published the article: Human IRF1 governs macrophagic IFN-u03b3 immunity to mycobacteria, in the Journal: (JOURNAL)
- what: The authors report here that AR complete IRF1 deficiency is a genetic etiology of isolated and severe MSMD.
- how: The authors investigated the cellular and molecular basis of human immunity to mycobacteria further by studying two unrelated children with a severe and unexplained form of isolated MSMD combining diseases due to both BCG and Mycobacterium avium in early . . .
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