Human loss-of-function variants in the serotonin 2c receptor associated with obesity and maladaptive behavior

HIGHLIGHTS

• who: Yang He from the (UNIVERSITY) have published the article: Human loss-of-function variants in the serotonin 2C receptor associated with obesity and maladaptive behavior, in the Journal: (JOURNAL) of 26/Oct/2021
• what: The authors demonstrate that 5-HT2CR is involved in the regulation of human appetite, weight and behavior. The authors provide evidence for a functional role of rare variants in HTR2C (encoding 5-HT2CR) in the development of obesity in humans.
• how: The authors studied rare HTR2C variants using gene-region and single-variant association analysis for obesity (BMI . . .
  

   

  

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